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Possible conformational changes of SERCA in response to Ca binding.

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posted on 2013-02-20, 02:36 authored by Zhanjia Hou, Zhihong Hu, Daniel J. Blackwell, Tyler D. Miller, David D. Thomas, Seth L. Robia

A. Opening of the cytoplasmic headpiece, increasing N- to A-domain distance. B. Closure of the cytoplasmic headpiece, decreasing domain separation. The cleft between the N- and A-domains is highlighted with dotted red lines.