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Object recognition memory after injection of Zn-CQ and ZnCl2 into the hippocampus.

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posted on 2013-02-20, 11:03 authored by Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando, Naoto Oku

Rats were placed for 10 min into an open field. Twenty-four hours after the open field exploration, vehicle (control), Zn-CQ (9.8 nmol/rat) in vehicle, and ZnCl2 (9.8 nmol/rat) in vehicle were bilaterally injected via injection cannulae into the hippocampal CA1 or the dentate gyrus of the rats at the rate of 0.5 µl/min for 1 min (n = 8–9). Thirty minutes after injection, rats were trained for 5 min and then tested for 3 min in the novel object recognition task 1 h after training. In the case of ZnCl2 injection into the CA1, 24 h after injection, rats were subjected to the test in the same manner. (A) The dots in the brain map show the representative points injected in the CA1 (orange) and the dentate gyrus (green). (B) Each bar and line represent the mean ± SEM. #, p<0.05, ##, p<0.01, ###, p<0.001, vs. training; *, p<0.05, control vs. Zn-CQ and ZnCl2 30 min vs. ZnCl2 24 h.

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