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OLE reduces plaque burden in the cortex and hippocampus of TgCRND8 mice.

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posted on 08.08.2013, 02:25 authored by Cristina Grossi, Stefania Rigacci, Stefano Ambrosini, Teresa Ed Dami, Ilaria Luccarini, Chiara Traini, Paola Failli, Andrea Berti, Fiorella Casamenti, Massimo Stefani

(A) Representative photomicrographs of Aβ42 immunopositive deposits. (n = 5/group, six sections from each mouse). Insets: high magnification images of representative plaques. Scale bars = 500 µm applies to all reconstructed images and 20 µm to all magnified images. (B) Quantitative analysis of total plaque area and plaque number in untreated and OLE-fed Tg mice (n = 6 for 3.5 and 6 months Tg mice). (C) ELISA: cortical levels of SDS- and formic acid-soluble Aβ40 and Aβ42 peptides in OLE-fed and untreated Tg mice. Both Aβ40 and Aβ42 levels were significantly decreased in OLE-fed Tg versus age-matched untreated Tg (n = 5/group) mice. *P<0.05, **P<0.01 and ***P<0.001. Data are reported as mean values ± S.E.M. mo = month-old.