Neuroprotective effects of 3α-DIOL corrective treatment against PAC-induced alterations in sciatic nerves and intraplantar skin.

(A-C) Chartbars show NF200 (A) or CNPase (C) expression level in sciatic nerve sections or IENF density in intraplantar skin sections (B) dissected from (VEH_crem + VEH_hpc)-, (PAC + VEH_hpc)-, (VEH_crem + 3α-DIOL)- and (PAC + 3α-DIOL)-treated rats. (A) Each value is expressed as mean (+ SEM) of actual counts for NF200-positive fibers detected in sciatic nerve sections. (B) Each value is expressed as mean (+ SEM) of IENF density (counts for PGP9.5-positive terminals) detected in intraplantar skin sections. (C) Each value is expressed as percent (+ SEM) of CNPase-positive cells bodies detected in sciatic nerve sections of control (VEH_crem + VEH_hpc)-treated rats. n=8 per group. *** p<0.001 vs (VEH_crem + VEH_hpc), ### p<0.001 vs (PAC + VEH_hpc).