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Major signaling network 1 associated with the proteins differentially expressed in brain-targeting 435-Br1 cells compared with parental MDA-MB-435 cells reported by the group of Dr. Sierra (Ref. [14]).

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posted on 2011-07-11, 02:30 authored by Feng Li, Olga V. Glinskii, Jianjun Zhou, Landon S. Wilson, Stephen Barnes, Douglas C. Anthony, Vladislav V. Glinsky

The network consists of 35 nodes, includes 12 out of 19 differentially expressed proteins (shaded red), and involves TNFα/TGFβ-, NFκB-, HSP-70-, and MAPK-associated major signaling pathways.