Irbesartan reduced the expression of stress-induced proinflammatory adipokines and restored adiponectin expression in adipose tissue.

Inguinal adipose tissues from control mice treated with vehicle or irbesartan (10 mg/kg/day), and stressed mice treated with vehicle or irbesartan (3 or 10 mg/kg/day) were analyzed by quantitative RT-PCR for angiotensinogen (A), MCP-1 (B), TNF-α (C), IL-6 (D), and adiponectin (E). Values are expressed relative to the vehicle-treated control mice. Plasma levels of MCP-1, TNF-α, and IL-6 from these groups were also measured. Data are mean ± SD of 10 mice for RT-PCR, 6 mice for ELISA per group. (A) *P<0.001, compared with the vehicle-treated control mice, **P<0.046, compared with the vehicle-treated and stressed mice, ^†P<0.042, compared with the stressed mice treated with a lower dose of irbesartan (3 mg/kg/day), respectively. (B) *P<0.001, compared with the vehicle-treated control mice, **P<0.001, compared with the vehicle-treated and stressed mice, ^†P<0.003, compared with the vehicle-treated and stressed mice, respectively. (C) *P<0.001, compared with the vehicle-treated control mice, **P<0.001, compared with the vehicle-treated and stressed mice, ^†P<0.004, compared with the stressed mice treated with a lower dose of irbesartan (3 mg/kg/day), ^††P<0.05, compared with the vehicle-treated and stressed mice, respectively. (D) *P<0.001, compared with the vehicle-treated control mice, **P<0.003, compared with the vehicle-treated and stressed mice, ^†P<0.004, compared with stressed mice treated with a lower dose of irbesartan (3 mg/kg/day), ^††P<0.002, compared with the vehicle-treated control mice, ^#P<0.02, compared with the vehicle-treated and stressed mice, respectively. (E) *P<0.001, compared with the vehicle-treated control mice, **P<0.05, compared with the vehicle-treated and stressed mice, respectively.