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Irbesartan reduced the expression of stress-induced proinflammatory adipokines and restored adiponectin expression in adipose tissue.

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posted on 31.12.2014, 03:06 authored by Motoharu Hayashi, Kyosuke Takeshita, Yasuhiro Uchida, Koji Yamamoto, Ryosuke Kikuchi, Takayuki Nakayama, Emiko Nomura, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toyoaki Murohara

Inguinal adipose tissues from control mice treated with vehicle or irbesartan (10 mg/kg/day), and stressed mice treated with vehicle or irbesartan (3 or 10 mg/kg/day) were analyzed by quantitative RT-PCR for angiotensinogen (A), MCP-1 (B), TNF-α (C), IL-6 (D), and adiponectin (E). Values are expressed relative to the vehicle-treated control mice. Plasma levels of MCP-1, TNF-α, and IL-6 from these groups were also measured. Data are mean ± SD of 10 mice for RT-PCR, 6 mice for ELISA per group. (A) *P<0.001, compared with the vehicle-treated control mice, **P<0.046, compared with the vehicle-treated and stressed mice, P<0.042, compared with the stressed mice treated with a lower dose of irbesartan (3 mg/kg/day), respectively. (B) *P<0.001, compared with the vehicle-treated control mice, **P<0.001, compared with the vehicle-treated and stressed mice, P<0.003, compared with the vehicle-treated and stressed mice, respectively. (C) *P<0.001, compared with the vehicle-treated control mice, **P<0.001, compared with the vehicle-treated and stressed mice, P<0.004, compared with the stressed mice treated with a lower dose of irbesartan (3 mg/kg/day), ††P<0.05, compared with the vehicle-treated and stressed mice, respectively. (D) *P<0.001, compared with the vehicle-treated control mice, **P<0.003, compared with the vehicle-treated and stressed mice, P<0.004, compared with stressed mice treated with a lower dose of irbesartan (3 mg/kg/day), ††P<0.002, compared with the vehicle-treated control mice, #P<0.02, compared with the vehicle-treated and stressed mice, respectively. (E) *P<0.001, compared with the vehicle-treated control mice, **P<0.05, compared with the vehicle-treated and stressed mice, respectively.

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