Figure_3.tif (635.47 kB)
Individual data points of PA stiffness measurements before and after 6-months of therapy with bosentan in PAH subjects (n = 14).
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posted on 2013-02-20, 07:05 authored by Edmund M. T. Lau, Nithin Iyer, Rahn Ilsar, Brian P. Bailey, Mark R. Adams, David S. CelermajerBosentan therapy was associated with no significant changes in PA stiffness indices: compliance (1.51±0.15×10–2 mm2/mmHg at baseline vs 1.56±0.15×10–2 mm2/mmHg at 6 months, p = 0.86), distensibility (0.31±0.04%/mmHg at baseline vs 0.30±0.03%/mmHg at 6 months, p = 0.92), elastic modulus (763±80 mmHg at baseline vs 756±81 mmHg at 6 months, p = 0.94), and stiffness index β (15.7±1.7 at baseline vs 18.1±1.3 at 6 months, p = 0.198). Data expressed as mean±SEM.