Immuno-histochemical staining, and disease-specific survival of fibulin-5 in patients with NPC.
figureposted on 2013-12-27, 02:45 authored by Chung-Feng Hwang, Li-Yen Shiu, Li-Jen Su, Yu-Fang Yin, Wei-Sheng Wang, Shun-Chen Huang, Tai-Jan Chiu, Chao-Cheng Huang, Yen-Yi Zhen, Hsin-Ting Tsai, Fu-Min Fang, Tai-Lin Huang, Chang-Han Chen
(A) The intensity of fibulin-5 expression in various tissues by immunohistochemical staining were evaluated in (a) normal tissue and tumor tissues of NPC patients with stage I (b), II (c), III (d), IV (e), lymph node-negative (f), and lymph node-positive (g) samples. Original magnification, 200×. (B) Survival of patients with high fibulin-5 expression (solid line) was significantly abbreviated in comparison to those with low expression (dashed line), with a statistically significant difference in survival (p = 0.003) by log-rank test.
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NPC cell linesPromotes Nasopharyngeal Carcinoma Cell MetastasisNPC cells overexpressing fibulinFLJ 10540 expressionPoor Prognosis Background Nasopharyngeal carcinomaMethods Standard semi-quantitative-RT-PCRphosphor-AKT activityNPC cellsfibulin -5-siRNA cellsNPC specimensfibulin -5-elicited cell growthFLJ 10540protein expression profiles