Histopathological manifestations of radiation enteropathy.

Xaliproden significantly reduced mucosal surface area (A) at 12 weeks after local irradiation of the small intestine, and enhanced radiation injury score (B), intestinal wall thickness (C) and serosal thickness (D) at 2 weeks and 12 weeks after irradiation. Average ± SEM, n = 5 (sham-irradiated) or 13–15 (irradiated). *p<0.05, ^†p<0.001. Representative micrographs of histopathological stainings are shown in Figure S3.