Histology.

After fixation of 18 month-old animals, 50 µm coronal sections were stained with Thioflavin T to label β-amyloid plaques. A) Swede mouse. White arrows indicate plaques in the orbital frontal cortex and anterior olfactory cortex, respectively. B) 18 month-old control mouse without any plaque staining. C) A Z-stack showing a 10 µm diameter plaque, one of the larger ones observed. D) A middle tufted cell of the olfactory bulb showing Tau tangle phenotype in a tested Tau mouse.