Hepatocellular apoptosis.

Apoptotic cell death, as assessed by TUNEL-analysis in animals at 24 h, 48 h and 5 d after pHx and daily administration of high dose EPO (5000 IU/kg bw iv; closed bars) or physiologic saline solution (open bars) (A). Representative images at day 5 after pHx of a saline-treated control (B) and an EPO-treated animal (C). Arrowhead indicate TUNEL-positive apoptotic hepatocytes. Bars represent 50 µm. Means±SEM; unpaired Student's t-test. * P<0.05 vs the saline-treated group at the respective time point.