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FGFR mediated proliferation of Mat1a

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posted on 30.11.2012, 02:33 authored by Nirmala Mavila, David James, Sarah Utley, Nguyen Cu, Orly Coblens, Katrina Mak, C. Bart Rountree, Michael Kahn, Kasper S. Wang

−/−cells are mediated in part through PI3K-AKT pathway. Serum-starved Mat1a−/− cells were treated with rFGF7/10 ± PI3K-AKT inhibitor LY294002 for detection and quantification of (A) pSer 552 β-CATENIN or (B) BrdU. Total and β-CATENIN/BrdU Positive cells were counted from 4–5 HPF images from 3 independent experiments and represented as relative % of control (n = 3, *p<0.001).