Experimental myograph record of isolated rat basilar arteries incubated with 5% CSF from patients with SAH with and without vasospasm.
figureposted on 28.01.2015, 03:21 authored by Barbara Assenzio, Erica L. Martin, Edgaras Stankevicius, Federica Civiletti, Marco Fontanella, Riccardo Boccaletti, Maurizio Berardino, AnnaTeresa Mazzeo, Alessandro Ducati, Ulf Simonsen, Luciana Mascia
The contractile force generated during exposure to increasing doses of ET-1 by Log (0.5 mol/L) every 5 min was higher at lower ET-1 concentrationsfor Vasospasm (bottom panel) compared to Non-Vasospasm (top panel).
Read the peer-reviewed publication
sahendothelin contractionendothelin concentrationsarteryETB receptor antagonistsETB receptor antagonismVasospasm Enhances Endothelin ContractionETB receptors.MethodsIntact rat basilar arteriesRat Cerebral Arteries IntroductionPrevious studiesCerebrospinal fluidetavasospasm endothelin contractionculture mediumrat basilar arteriesETB blockade