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Effect of claudin-18 knockdown on the proliferation and invasion of GC cells.

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posted on 2013-09-20, 01:30 authored by Tadayuki Oshima, Jing Shan, Takuya Okugawa, Xin Chen, Kazutoshi Hori, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Hiroto Miwa

(A) Claudin-18 siRNA treatment significantly induces cell proliferation. (B) Claudin-18 siRNA-transfected MKN74 cells show a significantly higher invasion ratio compared to control or control siRNA-transfected cells. Typical images are presented at the top. Bar = 500 µm. Each value represents the mean ± SD of 3 independent experiments. **P<0.01 vs. control or control siRNA.