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Effect of HFD feeding on fasting plasma insulin and glucose levels and glucose tolerance.

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posted on 21.01.2010, 02:03 by Robert Kleemann, Marjan van Erk, Lars Verschuren, Anita M. van den Hoek, Maud Koek, Peter Y. Wielinga, Annie Jie, Linette Pellis, Ivana Bobeldijk-Pastorova, Thomas Kelder, Karin Toet, Suzan Wopereis, Nicole Cnubben, Chris Evelo, Ben van Ommen, Teake Kooistra

Plasma insulin (A) and glucose (B) levels determined after a 5 hr fasting period. A glucose tolerance test (GTT) (C) was performed 2.5 weeks prior to inclusion into the study (not shown) and each animal underwent a second GTT, in week 0, 1, 6, 9, and 12 of HFD feeding (n = 15 each). After a 5 h fast, animals received 2 g glucose/kg body weight (i.p.). Glucose was recorded at the time points indicated and the area under the curve (AUC) (D) was calculated. Values are means ± SEM. **P<0.01; *P<0.05