EAE severity depends upon TNFR expression.

EAE was induced with MOG^35–55 in TNFR1^-/-, TNFR2^-/- and WT mice and the resulting disease was assessed daily using a score from 0 to 5, until 21 days after the onset of neurological symptoms. TNFR1^-/- mice had a much less severe disease course when compared to WT mice, whereas TNFR2^-/- mice showed more severe symptoms than WT mice (A). These observations were reflected in the significantly reduced cumulative EAE score in TNFR1^-/- mice, and the significantly increased cumulative score in TNFR2^-/- mice (B). Furthermore, TNFR1^-/- mice were more resistant to disease induction than both TNFR2^-/- and WT mice (C). * P<0.05, TNFR1^-/- n = 13; TNFR2^-/- n = 8; WT n = 14.