Determination of minimal effective dose of UV-4 against influenza.
Female BALB/c mice were infected with ~1xLD90 of INFV A/Texas/36/91 (H1N1) via IN instillation. Mice (n = 10/group) were orally treated TID for 10 days with 100, 80, 60, 40, 20 or 10 mg/kg of UV-4 or vehicle or twice daily for 5 days with oseltamivir phosphate at 20 mg/kg. (A) Survival data is plotted as percent survival against days post infection. B) The mean health score for each group are plotted against days post infection. C) The mean percent temperatures for each group are plotted compared to their percent temperature on day 0 (baseline) against days post infection and D) The mean percent weights for each group are plotted compared to their percent weight on day 0 (baseline) against days post infection.