Dependency of the resveratrol/piceatannol effects on the substrate sequence and the type of acyl modification.

A Sirt5-dependent deacetylation of p53-Lys382 peptide is not affected by resveratrol. B+C In contrast to its stimulated deacetylation activity, Sirt5’s deacylation activity against succinylated FdL1 (B) and Prx1-Lys197 (C) peptides is inhibited by resveratrol and piceatannol. Error bars represent standard errors of linear fits to time-series experiments.