Figure_3.tif (865.06 kB)
Comparison of PSV and VI assays across viruses.
figure
posted on 2012-05-09, 00:29 authored by Leo Heyndrickx, Alan Heath, Enas Sheik-Khalil, Jose Alcami, Vera Bongertz, Marianne Jansson, Mauro Malnati, David Montefiori, Christiane Moog, Lynn Morris, Saladin Osmanov, Victoria Polonis, Meghna Ramaswamy, Quentin Sattentau, Monica Tolazzi, Hanneke Schuitemaker, Betty Willems, Terri Wrin, Eva Maria Fenyö, Gabriella Scarlatti(A) circular “radar” plots. Lines from the centre represent an axis for each virus. The geometric mean IC value for PSV (blue lines) and PBMC (red lines) against each virus is plotted, and the points joined. The scale is set such that the centre represents no neutralization and the concentric grid-lines are 2-fold dilution steps moving out to highest neutralization at the edge. (B) and (C) Ranking of viruses for relative sensitivity to neutralization was done by calculating geometric mean IC50s across laboratories (grouping PSV and PBMC separately). (B) Ranking by TriMab and (C) ranking by plasma (means over ARP515-522). The scale is set such that the most neutralization sensitive viruses are at the top.
