COX-2 dependent induction of CGRP release in trigeminal ganglia neurons.
Stimulation with IL-1β leads to the synthesis of COX-2 in trigeminal neurons and glial cells followed by PGE2 release. PGE2 in turn activatesTGN to release CGRP. PGE2 and CGRP release can be blocked by selective (parecoxib) or non-selective (indomethacin) COX-2 inhibitors. The attenuation of CGRP and PGE2 release could contribute to the effect of COX-inhibitors to revoke sensitization and to abort pain.