COX-2 dependent induction of CGRP release in trigeminal ganglia neurons.

Stimulation with IL-1β leads to the synthesis of COX-2 in trigeminal neurons and glial cells followed by PGE₂ release. PGE₂ in turn activatesTGN to release CGRP. PGE₂ and CGRP release can be blocked by selective (parecoxib) or non-selective (indomethacin) COX-2 inhibitors. The attenuation of CGRP and PGE₂ release could contribute to the effect of COX-inhibitors to revoke sensitization and to abort pain.