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Basal synaptic transmission is altered after kainate treatment.

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posted on 2013-02-19, 21:01 authored by Luz M. Suárez, Elena Cid, Beatriz Gal, Marion Inostroza, Jorge R. Brotons-Mas, Daniel Gómez-Domínguez, Liset Menéndez de la Prida, José M. Solís

(A) Superposition of fEPSPs (5 consecutive responses) evoked by various stimulus strengths in single representative experiments obtained from control, resistant and epileptic rat. Stimulus-response curves for fEPSP (B) and the fiber volley FV (C) obtained in slices from the control (16 slices from 11 rats), resistant (15 slices from 10 rats) and epileptic (16 slices from 13 rats) groups. (D) Input-output curves were created by comparing FV amplitudes with fEPSP slopes from data depicted in B and C. (E) FV/fEPSP ratios for different ranges of stimulus strength shown in D confirm that resistant rats present a reduction of synaptic efficacy when compared with control animals (*P<0.05).


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