Antibody A06 therapy protects DBA/2 mice from death by 2009 pandemic H1N1 influenza infection.
DBA/2 mice were infected with 3.3MLD50 of A/Netherlands/602/2009 and treated with a single administration of antibody A06 1 day (A) or 2 days (B) post-infection. Three different A06 concentrations were tested along with vehicle (PBS) and non-specific IgG controls. Animals were monitored for survival (left panels) and weight (right panels) over a 14 day period. Treatment groups (n = 5) are labeled as in Figure1B and 2C. Open blue squares- 25 mg/kg antibody A06, open red circles- 10 mg/kg antibody A06, open green triangles- 2.5 mg/kg antibody A06, black filled circles- PBS vehicle control, open orange diamonds- 25 mg/kg human IgG control.