Figure_3.tif (186.17 kB)
Angiotensin II-induced ANP mRNA expression in neonatal cardiomycytes derived from KO and WT mice.
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posted on 2012-10-29, 00:41 authored by Daniel Biermann, Andreas Heilmann, Michael Didié, Saskia Schlossarek, Azadeh Wahab, Michael Grimm, Maria Römer, Hermann Reichenspurner, Karim R. Sultan, Anna Steenpass, Süleyman Ergün, Sonia Donzelli, Lucie Carrier, Heimo Ehmke, Wolfram H. Zimmermann, Lutz Hein, Rainer H. Böger, Ralf A. BenndorfAngiotensin II (Ang II, 10−7 mol/L)-stimulated cardiomyocytes from KO mice show a similar increase in ANP mRNA expression as compared to WT mice, but have higher basal ANP mRNA levels. Angiotensin II-induced ANP mRNA expression is significantly reduced by AT1 receptor antagonist losartan, but not by AT2 receptor antagonist PD123,319 (10−7 mol/L each). * P<0.05 vs. untreated WT or KO cardiomyocytes, respectively, § P<0.05 vs. WT control, $ P<0.05 vs. Ang II. Data are shown as mean ± SD; n = 6–8.
