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An alternative TCA cycle generates oxalate and ATP as a consequence of Al toxicity.

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posted on 2013-02-21, 04:21 authored by Ranji Singh, Joseph Lemire, Ryan J. Mailloux, Daniel Chénier, Robert Hamel, Vasu D. Appanna

(↓) represents a decrease in enzyme activity whereas (↑) represents an increase in activity. AGODH  =  acylating glyoxylate dehydrogenase, SCS  =  succinyl-CoA synthetase, ICL  =  isocitrate lyase, MS  =  malate synthase, ACN  =  aconitase, NAD-ICDH  =  NAD-dependent isocitrate dehydrogenase, SDH  =  succinate dehydrogenase, FUM  =  fumarase, OCT  =  oxalate CoA-transferase, and KGDH  =  α-ketoglutarate dehydrogenase, CS  =  citrate synthase, MDH  =  malate dehydrogenase.

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