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Ablation of XBP1 does not significantly affect the MCDS phenotype in C/X mice.

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posted on 15.09.2015, 03:14 by Trevor L. Cameron, Katrina M. Bell, Irma L. Gresshoff, Lisa Sampurno, Lorna Mullan, Joerg Ermann, Laurie H. Glimcher, Raymond P. Boot-Handford, John F. Bateman

(A-C) Tibial epiphyseal cryosections from 2 week Wt, Xbp1CartΔEx2, ColXN617K and C/X mice stained with (A) haematoxylin and eosin (H&E), or by immunofluorescence using (B) anti-collagen II or (C) anti-collagen X antibodies; B—Bone; HZ—Hypertrophic Zone; PZ—Proliferative Zone; SCO—Secondary Center of Ossification. (D-F) Quantification of growth plate (D) resting zone, (E) proliferative zone, and (F) hypertrophic zone lengths in mutant and Wt mice; N = 3 for each genotype; statistical analysis performed using Student’s t test.

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