A new role for clathrin-coated pits in the early phases of EGFR signaling.

Upon stimulation with ligand, epidermal growth-factor receptors are recruited to clathrin-coated pits, where their phosphorylation is amplified by clustering. Phosphorylated receptors are able to escape the clathrin-coated pits leading to an amplified EGFR signal in surrounding plasma membrane.