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μ-CT analysis and serum markers after ovariectomy.

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posted on 28.05.2020, 17:24 by Takeshi Moriishi, Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano, Tomoka Hasegawa, Toshihiro Miyazaki, Wenguang Liu, Ryo Fukuyama, Yuying Wang, Hisato Komori, Xin Qin, Norio Amizuka, Toshihisa Komori

Sham operation or ovariectomy (OVX) was performed at 5 weeks of age and mice were analyzed at 11 weeks of age. (A-D) μ-CT analyses of femurs in wild-type and Ocn–/–mice with sham operation or OVX. μ-CT images of femoral distal metaphyses (A) and mid-diaphyses (B) are shown. Scale bars = 500 μm. C, Trabecular bone parameters, including the trabecular bone volume (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N). D, Cortical bone parameters including cortical thickness (Ct. Th), the periosteal perimeter (Ps.Pm), and endocortical perimeter (Ec.Pm). wt sham: n = 9, wt OVX: n = 8, Ocn–/–sham: n = 6, Ocn–/–OVX: n = 7. X symbols in box plots show outliers. (TIF)