pbio.3002504.s001.tif (1.16 MB)
Widespread deterioration of neurons within the Drosophila visual system with age.
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posted on 2024-03-13, 17:42 authored by Pilar Okenve-Ramos, Rory Gosling, Monika Chojnowska-Monga, Kriti Gupta, Samuel Shields, Haifa Alhadyian, Ceryce Collie, Emilia Gregory, Natalia Sanchez-Soriano(A and B) Axons and terminals of the L2 neurons within the medulla of the optic lobe from young (5–7 days, A) and old specimens (28–30 days, B), labelled with the plasma membrane marker myr-Tom (myr). In aged specimens, axons show thinning (arrow heads) and swellings (asterisks; dashed blue boxes shown as 1.7-fold magnified images below). Scale Bar for A and B can be found in A bottom right = 10 μm.
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vertebrate animal modelsslow process duepredominant risk factormany neurodegenerative diseaseskey lesion siteconfer aged specimensbinding factors taumorphological changes arisingincluding parkinson ’div >< prelated neuronal decayimprove neuronal decaymt cytoskeleton offersneuronal ageing hallmarksneuronal microtubuleneuronal ageingcytoskeleton precedeschanges beginalzheimer ’ageing hallmarkscytoskeletal decaywork suggestsunderlying mechanismstime requiredsynaptic terminalspromising targetoutperform ageoccur withinnatural ageingmt networksmt maintenancematched controlslarge amountimpacting qualitygenetic manipulationsfunctional lossdrosophila cognitive functionsaxonal calibreageing neuronsage mammalian
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