pone.0297666.s002.tif (10.44 MB)
Volcano plots of acrosome, capacitation and motility assays.
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posted on 2024-02-20, 18:40 authored by Franz S. Gruber, Anthony Richardson, Zoe C. Johnston, Rachel Myles, Neil R. Norcross, David P. Day, Irene Georgiou, Laura Sesma-Sanz, Caroline Wilson, Kevin D. Read, Sarah Martins da Silva, Christopher L. R. Barratt, Ian H. Gilbert, Jason R. SwedlowUpper panel indicates 10 μM, lower plot panels indicate 30 μM. Incubation times for assays are 3h with compound for Acrosome 2 assay and Motility (non-capacitating) (PM = progressive motility), and 30 min for the Capacitation assay (HA = hyperactive motility, PM = progressive motility). Dotted line indicates significance levels of 0.05. Any point above dotted line is indicated in magenta. Buffer conditions are indicated below Plot title (capacitating vs. non-capacitating).
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several automated highdifferent physiological statesallows quantitative comparisonssmall molecule librarycomplementary functional assayssperm toolbox compoundsthroughput assayssmall moleculessperm toolboxsperm motilitysperm functionresulting datasetspathways operatingmeasure stimulationline rkey advantageinhibit fertilityinfertility treatmentsgenerate fingerprintsexperimental conditionseither improvebased appassayed togetherassayed motilityacrosome reaction
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