pbio.3002486.s008.tiff (194.94 kB)
Vancomycin-mediated depletion of SCFA-producing bacteria does not affect survival of IL-1β -/- mice.
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posted on 2024-01-18, 18:41 authored by Mor Zigdon, Jasmin Sawaed, Lilach Zelik, Dana Binyamin, Shira Ben-Simon, Nofar Asulin, Rachel Levin, Sonia Modilevsky, Maria Naama, Shahar Telpaz, Elad Rubin, Aya Awad, Wisal Sawaed, Sarina Harshuk-Shabso, Meital Nuriel-Ohayon, Mathumathi Krishnamohan, Michal Werbner, Omry Koren, Sebastian E. Winter, Ron N. Apte, Elena Voronov, Shai Bel(A) Survival of vancomycin-treated mice infected orally. (B) Salmonella C.F.U. in the indicated organs of IL-1β -/- mice 17 d.p.i. Each dot represents a mouse. (C) Survival of WT mice infected with Salmonella isolated from IL-1β -/- mice 21 d.p.i. **P < 0.01. (A) Mantel–Cox test. These data are representative of 1 experiment. d.p.i., days post-infection. Numerical values are in S1 Data.
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sup >-/-reduced tissue damageoutcompete commensal microbesintracellular pathogens likeinactivator carboxypeptidase nfatty acid oxidationepithelial cell metabolismdiv >< pchain fatty acidswitching energy productionprocess via ilestablish gut colonizationacute gastrointestinal infectionmice lacking il1β induces expression1β productionexploits iluninfected patientstyphimurium triggerssalmonella remains unclearrecruit neutrophilsprevented depletionpatients sufferingintestinal defenseinterleukin 1βhealthy individualsfindings identifyexpression correlatescpn1 ).controlling mortality1β signaling1β ).1β (<
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