Vaccine regimens drive distinct antibody functional profiles.

A: The violin plots depict six functional assays which were performed against a gp140 ConS antigen at peak immunogenicity (Month 6.5/7 post vaccination initiation), lines are indicating median and quartiles. The different trials and trial arms are depicted along the x-axis, each trial arm is shown in a different color, placebo levels are represented by the dotted line. B: Each line graph depicts one effector function over time for each trial arm. Time points include baseline (B), post prime (PP), post-boost (PB) and durability (D). For trial 078, PP indicates Month 1, after the first but before the second prime administration. The lines represent the median of each trial arm, with each trial arm depicted in a different color. The stacked bar graphs show the polyfunctional profile across all trial arms at peak immunogenicity (C) or the durability time point (month 12) (D), calculated as the number of functions within the group above the overall median across the whole cohort for each function. Colors indicate the polyfunctionality from light (0,1,2 functions) to dark (more polyfunctional).