ppat.1009543.g006.tif (4.46 MB)
Vaccine-elicited mAbs target V2 region using a lateral approach with slightly different angles of approach.
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posted on 2021-09-24, 18:00 authored by Safia S. Aljedani, Tyler J. Liban, Karen Tran, Ganesh Phad, Suruchi Singh, Viktoriya Dubrovskaya, Pradeepa Pushparaj, Paola Martinez-Murillo, Justas Rodarte, Alex Mileant, Vidya Mangala Prasad, Rachel Kinzelman, Sijy O’Dell, John R. Mascola, Kelly K. Lee, Gunilla B. Karlsson Hedestam, Richard T. Wyatt, Marie PanceraSide and top surface/cartoon representation of one gp120 (yellow)-gp41 (tan) 16055 NFL protomer with Fab bound: (A) D11A.B5 (pink), (B) D15.SD7 (blue), (C) D19.PA8 (orange) and (D) VD20.5A4 (raspberry) showing the angles of approach of each mAb. (E) Superimposition of gp120-gp41 16055 NFL protomer with D11A.B5 (pink), D15.SD7 (blue) and D19.PA8 (orange) onto VD20.5A4-bound gp120-gp41 protomer. (F) Summary of the mAbs angles of approach.
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variable region 2structural analysis revealsray crystallography identifiednative flexibly linkedguiding immunogen designfacilitate trimer redesigndifferent tier 2crystal structures revealedatomic level information1 envelope glycoproteinpotent neutralizing capacitypotent autologous neutralizationautologous neutralization elicitedpotentially elicit crossinduced antibodies derivedanalyzed monoclonal antibodiesreactive neutralizing antibodiesvaccine development aimedv2 segment adoptsdiv >< p16055 nfl trimerautologous viruseliciting cross16055 strainantibodies targetneutralizing hivstructurally relatedstain empotencies rangingnabs ).multiple anglesmolecular mechanismshuman primatesglycan shieldconserved regionscommon epitopebetter targetbased immunogens68 μg
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