pgen.1009802.s001.tif (208 kB)
VLDL-TG secretion in Lipg-/- mice.
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posted on 2021-09-20, 17:46 authored by Sumeet A. Khetarpal, Cecilia Vitali, Michael G. Levin, Derek Klarin, Joseph Park, Akhil Pampana, John S. Millar, Takashi Kuwano, Dhavamani Sugasini, Papasani V. Subbaiah, Jeffrey T. Billheimer, Pradeep Natarajan, Daniel J. RaderA. Plasma triglycerides in mice at the indicated timepoints following intraperitoneal injection of poloxamer P407, a competitive inhibitor of LPL activity. Plasma TGs were measured by colorimetric biochemical assays. B. VLDL-TG secretion rates calculated from the slope of the curves from (A) using the 1, 2, and 4 hour timepoints. **P<0.01, repeated factor 2-way ANOVA comparing WT and Lipg-/- groups (A). *P<0.05, student’s unpaired T-test comparing WT and Lipg-/- groups (B). Data is expressed as mean ± S.E.M.
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vital energy sourcestgs harboring longprovide fatty acidsfatty acids used>< sup ><data positions elhydrolyzing trl tgsmice demonstrated accumulationmediate efficient lipolysisfunction missense variantexcess dietary tgdiv >< pgenetic el loss>el reconstitutionel lipolysis>, eltrl metabolismtrl clearancevivo vitro rich lipoproteinsprimary rolepostprandial plasmalipoprotein lipaselipoprotein classeslipidomic analyseslipg key collaboratorfat fedendothelial lipasecirculating reservoirs>, p
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