ppat.1009165.g007.tif (2.8 MB)
VHJH precursors for anti-SARS-CoV-2 nAbs are frequent within COVID-19 infected and uninfected BCR repertoires.
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posted on 2021-02-11, 18:28 authored by Michael Mor, Michal Werbner, Joel Alter, Modi Safra, Elad Chomsky, Jamie C. Lee, Smadar Hada-Neeman, Ksenia Polonsky, Cameron J. Nowell, Alex E. Clark, Anna Roitburd-Berman, Noam Ben-Shalom, Michal Navon, Dor Rafael, Hila Sharim, Evgeny Kiner, Eric R. Griffis, Jonathan M. Gershoni, Oren Kobiler, Sandra Lawrynowicz Leibel, Oren Zimhony, Aaron F. Carlin, Gur Yaari, Moshe Dessau, Meital Gal-Tanamy, David Hagin, Ben A. Croker, Natalia T. Freund(A) The VJ gene frequencies of anti-SARS-CoV-2 antibodies was calculated and compared to the frequency of all other VJ genes. Frequencies are shown in COVID-19 patients, in healthy matured, as well as in healthy naïve B cells. (B) The table lists the individual frequencies of every nAb IGHV/JH combination in each one of the three BCR datasets (COVID-19 infected, n = 13, COVID-19 un-infected, mature BCR, n = 7, COVID-19 un-infected naïve BCR, n = 42).
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COVID -19ACEb cell receptorcombination antibody therapyCOVID -19 convalescent donorsB cell responsesMulti-clonal SARS-CoV -2 neutralizationBCRELISAnAbs germline VHJH precursorspatients 1.5 months post SARS-CoV -...block SARS-CoV -2 infectionmulti-clonal neutralizing responsesSpike receptor binding domainRBD
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