pcbi.1011655.s009.tif (14.53 MB)
Using top 10 and 50 frequencies for average Person Correlation for BPTI and EGFR.
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posted on 2023-11-27, 19:10 authored by Hoda Akl, Brooke Emison, Xiaochuan Zhao, Arup Mondal, Alberto Perez, Purushottam D. DixitPanels A, B. The average Pearson correlation coefficient between frequencies of the top 10 amino acid combinations of order n (x-axis) averaged across different combinations (y-axis). Panels C, D Same as A and B but using the frequencies of the top 50 amino acid combinations to obtain the average Pearson correlation.
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unlike current methodsstable 3d structuremodeling moderately sizedlow sequence coverageinformative latent spacecorresponding natural ensemblesamino acid covariationgenerative nonlinear tensoraccurate generative modeldiv >< pprotein sequence familiesprotein familiesgenerative modelsprotein scientistsrelated obstacleslarge proteinsimportant toolfactorization engineers alike
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