UNC0638 abrogates NSP1-mediated downregulation of immune related.

A.) Volcano plots showing suppression of type I and III interferon genes by NSP1 (left panel) and attenuation of the suppression following UNC0638 treatment. RNA-seq experiments in each condition are biological triplicates. B.) Profiling of secreted cytokines showing restoration of antiviral genes suppressed by NSP1. C.) Cumulative distribution frequency plots showing the effect of UNC0638 on H3K9me2 marks (-0.26; p value <0.0001), H3K9me3 marks (-0.06; p value = 0.075) and PolII occupancy (+0.09; p value < 0.001) on the top genes H3K9me2-enriched after NSP1 expression.