Treatment resulted in minimal retrograde blood flow within the MCA at 24 hours post-pMCAO.

A, Experimental schema with LSI representative cases for treated (top) and untreated (bottom) subjects, before (left) and 24 hours after (right) pMCAO. Treated (n = 4) and untreated (n = 3) subjects are similar in that there was reduced blood flow at 24 hours post-pMCAO. B, Quantification of laser speckle velocity for both groups, represented as a percentage of baseline values. The reduction in blood flow was significant for all subjects. Green arrows indicate the direction of whisker movement during stimulation.