ppat.1012031.s005.tiff (502.09 kB)
Transcriptional response of IECs to infection with non-damaging and non-filamentous C. albicans.
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posted on 2024-03-01, 21:05 authored by Jakob L. Sprague, Tim B. Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L. Priest, Antzela Tsavou, Gianni Panagiotou, Julian R. Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard HubeGenes differentially expressed when comparing the non-damaging ece1Δ/Δ and the non-filamentous efg1ΔΔ/cph1ΔΔ strains to their respective WT strains (ece1Δ/Δ compared to WT (BWP17) and efg1ΔΔ/cph1ΔΔ compared to WT (SC5314)). The data are shown as the Log2(fold-change) of infected cells with the different strains compared to uninfected IECs. Asterisks indicate genes with statistically significant differences in expression (DESeq2 p < 0.05).
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process remain unclearmicrobial mechanisms behindhuman mucosal surfacesfull virulence potentialfrequently causes infectionsdiv >< pcertain predisposing conditionsopportunistic fungal pathogenpeptide toxin candidalysinintestinal epithelial barrierfungal zinc acquisitionintestinal epithelial cellsmediated barrier protectionrestrict fungal translocationcandida albicans iecs limits candidalysiniecs counteract damagecell damage mediatedintestinal barrieridentified fungalalbicans mediated damagenutrient acquisitioncells servesmediated maintenanceece1 c cell damageusing dualtranslocation acrosstnf signalingspecific responserna sequencingmediates maintenancemain sourceharmless commensalencoding genedisseminated candidiasisdata suggestcell junctions
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