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Transcription of the proviral plus-strand is accompanied by a loss of contacts between the provirus and flanking host chromatin.

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posted on 2024-03-01, 18:46 authored by Hiroko Yaguchi, Anat Melamed, Saumya Ramanayake, Helen Kiik, Aviva Witkover, Charles R. M. Bangham

(A) q4C profiles of Tax−(upper panel) and Tax+ (lower panel) cells from clone 11.63. (B) q4C profiles of non-expressing (GFP–) (upper panel) and provirus-expressing (GFP+) cells (lower panel) from clone d2EGFP-11.50. Vertical axes show the normalized frequency of chromatin contacts between the provirus and the host genome.

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    PLOS Pathogens

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    unique genomic siteremained unknown whetherinfected individual carriesdiv >< pcopy provirus integrated4 nearby host chromatinflanking host genomeinduced host transcriptionhost genomeflanking genomequantified hostchromatin loopschromatin loopingreversible disruptionreducing provirusq4c ),previously showedexpressing populationexerted simplycells positivecell populationcell clones3d structure

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