ppat.1009312.g006.tif (1.59 MB)
Toremifene and fluoxetine show synergism against pseudotyped WT-EBOV but not WT-MARV.
figure
posted on 2021-02-04, 19:09 authored by Adam Schafer, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E. Ramirez, Norton P. Peet, Michael Caffrey, Gregory R. J. Thatcher, Erica Ollmann Saphire, Han Cheng, Lijun Rong(A) Dose-dependent response of 6 x 6 concentration matrix of toremifene and fluoxetine combination in pseudotyped WT-EBOV and 3D synergism score plot (B) using Loewe’s additive model. Synergy score means % over expected additive effect; (C) Dose-dependent response of 6 x 6 concentration matrix of toremifene and fluoxetine combination in pseudotyped wild-type Marburg virus and3D synergism score plot (D) using Loewe’s additive model. Data was collected and averaged from three individual biological replicates.
