pgen.1010777.s004.tif (9.03 MB)
Top 30 valve genes in the CS16 and CS19 datasets.
figure
posted on 2023-11-27, 19:20 authored by Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J. Cockell, Maureen A. Kane, Steven Lisgo, Deborah J. HendersonA) Top 30 DEGs in the CS16 (left list) and CS19 (right list) compared to the combined dataset. B) At both stages, GenePaint data suggested that genes already known to be expressed in the valve region (blue letters) were clearly and specifically expressed in the valve region, whereas novel genes were less strongly expressed (black letters) or were undetectable, particularly at CS16 (e.g. CS16: RAB32, TIPARP, ZBT58A; CS19:GLT8D2).
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xlink "> abnormalitiesusing spatial transcriptomicsseveral days apartnovel &# 8221highlight &# 8220common congenital defectsgenomic data analysesexpression data confirmarterial valves formdeveloping heart valvesdeveloping arterial valvesrelated genes maydifferentially expressed genesmouse atrioventricular valvesarterial valve defectssignalling pathways importantarterial valve developmentarterial valvesgenes importantdeveloping embryodata suggestsvalve developmentmouse knockoutsmouse genomecardiac developmentvalve transcriptomestiny structuresstill muchsmall sizesignificant causerelative inaccessibilitylater lifeincluding fourhuman gestationhuman embryosgreat majoritygenetic levelcausative variantsaccurately dissecting
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