pgen.1009992.s002.jpg (1.6 MB)
Toll10B rescues progenitor cell number in the absence of PGRP-SA.
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posted on 2022-01-10, 18:26 authored by Shivohum Bahuguna, Magda Atilano, Marcus Glittenberg, Dohun Lee, Srishti Arora, Lihui Wang, Jun Zhou, Siamak Redhai, Michael Boutros, Petros LigoxygakisExpressing a UAS- transgene of a gain of function version of the Toll receptor (Toll10B) in progenitor cells activated ISC division in the absence of functional PGRP-SA, as indicated by staining midguts of 5-day old females with an anti-phospho-histone-3 antibody (PH3+) (left panel) and quantified (right panel). Of note, that ISCs are the only PH3+ cells of the intestinal epithelium.
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results give insightsenabled fat catabolismdiv >< prestored bacterial densityintestinal bacterial densitymaintain indigenous bacteriabacterial recognition upstreamtoll activated 4eκb signalling resultedbacterial recognitionreduced densitydownstream signallinggut bacteriacommensal bacteriatranscriptional targettoll activitypharmacological inhibitionmetabolic parametershealthy fliesgut setsfeedback loopdrosophila >, deficiency
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