pone.0257299.g001.tif (366.76 kB)
Timeline of the study in normal (non-diabetic) and diabetic pigs, showing the growing pre-phase with the two diets to select groups with balanced growth; the induction of D in a subset of animals and the allocation to the treatment groups.
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posted on 2021-10-20, 20:03 authored by Sietse J. Koopmans, Heleen M. M. van Beusekom, F. Josef van der Staay, Gisabeth Binnendijk, Marcel Hulst, Zlaw Mroz, Mariette T. Ackermans, Lambertus BenthemAt week -3, 38 out of 60 pigs with comparable body weight were balanced and selected for the experimental treatments and placed in metabolic cages. At week 0, start of the experimental treatments. L = low fat, low sugar diet, F = fast-food, D&N = diabetic and non-diabetic pigs.
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nutritional life stylemean ± semaorta fatty streaks57 ± 012489 ± 131276 ± 145193 ± 55184 ± 62107 ± 31type (< blant -< b79 ± 048 ± 005 ± 0pfs fa f dpfs dfa df )9 ± 22 ), intermediate13 ± 2type diet elevateddiet partially corrected6 ), intermediate49 ± 154 ± 4136 ± 404 ± 04 ± 24 ± 5diet (< b2 ± 0diabetes (< bns ): low6 ± 440 %), cholesterol4 ± 16 ± 01 ± 0group b ),2 ± 11 ± 25 pig groupsseveral abnormalities relatedmediated glucose disposalliver triglyceride concentrationfasting plasma tnf16 ), intermediategroup 5 switched7 %), intermediate7 ± 1p 8 ± 225 %), sucroseslow carbohydrate dietmetabolic health exceedgroup 3 receiveddiabetic pigs fedgroup b pigslow sucrose dietdiabetic medication metformin25 %),group b5 groupsgroup 2group 1diabetic medication0 ).5 %)diet predisposedmetabolic healthfed eitherdiabetes amplified40 %)15 %)1 ).normal pigsdomestic pigs7 weeks7 ).2 gxlink ">study investigatedsole antiprotein contentnumerical trendmetabolic syndromemeal intolerancelowly digestibleliver weightish oilgrowing prefish oilcorrecting effectscardiovascular homeostasiscardiometabolic abnormalitiescarbohydrate compositionbody weightbeneficial effects40 mg19 ).
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