pcbi.1011151.g003.tif (119.22 kB)
Time courses with alternating TP53 levels.
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posted on 2024-01-08, 18:23 authored by Paul F. Lang, David R. Penas, Julio R. Banga, Daniel Weindl, Bela NovakDNA damage was simulated by activating TP53. The first activation corresponds to G1 phase, the second to G2 phase. Inactivation of TP53 allows continued proliferation. For better visualisation the G1 checkpoint was lifted before the steady state was reached. Model available in the /versions/v3.1.0/cell_cycle_v3.1.0.bngl file of the cell_cycle_model GitHub repository.
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powerful computational toolsobtained excellent agreementsimprove parameter identifiabilitycomputational models providemammalian cell cyclefull cell cyclecomprehensive model structurecell cyclemodel structurexlink ">work aimsvalidation methodologytwo compartmentstime coursessystemic descriptionreusable ruleresolved dynamicsqualitatively explainspetab specificationparticularly systematicmodel parametersdrug discovery16 observables1 cells
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