Time courses of the core cell cycle model.

a, b Core cell cycle model at CycD = 1 AU_D. c, d Simulation of mitogen deprivation. The full cell core model was simulated as in (a, b) until 610 min (c) and 620 min (d), respectively. CycD as proxy for mitogen availability was then turned to 0 AU_D and the simulation was continued until 1500 min. e Full cell cycle model with CycE knockout. f Full cell cycle model with CycA knockout. Blue ticks at the top indicate the approximate location of the M/A transition. All models use identical parametrization (except for CycD). For variable abbreviations please refer to Table A in S1 Appendix. The model and parameters are available in the /versions/v1.0.0/ directory of the cell_cycle_model GitHub repository.