Therapeutic effects of liposomal formulations in BALB/c mice against a TUBO tumor model.

Two weeks after inoculation of 5 ×105 TUBO cells to five mice in each group, different liposomal formulations were administrated three times with two-week intervals. After the first injection, the mice were challenged and tumor size was calculated based on three dimensions. (A) Tumor growth was measured two times every week. (B) The survival of mice was followed for 91 days. The data indicate the mean ±SEM(n = 5). ***p<0.001 and ****p<0.0001; denote significant difference from the HEPS-dextrose 5% group.