pone.0261170.g007.tif (452.87 kB)
The sequence context of the RBMX2 (11,688bp) gene.
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posted on 2021-12-16, 18:49 authored by Pia Laine, William J. Rowell, Lars Paulin, Steve Kujawa, Denise Raterman, George Mayhew, Jennifer Wendt, Daniel L. Burgess, Timo Partonen, Tiina Paunio, Petri Auvinen, Jenny M. Ekholm(a) The RBMX2 gene sequence was aligned against itself. The red lines represent sequence homologies between sequences on the same strand, while blue lines represent sequence homologies on the antisense strand. The 330bp Alu element deletion in intron 3 is marked with a black box. (b) The intron 3 sequence is aligned in the RBMX2 gene against itself. Again, the 330bp deletion is marked with a black box. (c) The 330bp deleted Alu element sequence is aligned against itself.
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read single moleculeleast four generationsentire 12mb regionadditional evidence supported9kb fragments spanning12mb genomic regionthree variants emergedrepresented common variantscandidate structural variantscritically linked regionperfect segregation among>) gene foundlinked 2 (<near genes belongingfamily segregates bd201 variantslinked (<showed nearleading candidateextended familysignificantly linkedxlink ">used longthird svrbmx2 rbmx intron 3intron 1increased riskgpr101 )genetic subg proteinfully characterizef9 disease haplotypedisease developmentcould explaincontributing directlychromosome xq24bipolar disorderbd typealuya5 )alu affected individuals
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