pcbi.1011919.s004.tif (189.17 kB)
The rat-specific heart model captures changes in DEGs and metabolomics.
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posted on 2024-02-29, 18:53 authored by Bonnie V. Dougherty, Connor J. Moore, Kristopher D. Rawls, Matthew L. Jenior, Bryan Chun, Sarbajeet Nagdas, Jeffrey J. Saucerman, Glynis L. Kolling, Anders Wallqvist, Jason A. Papin(A) The number of DEGs (FDR < 0.1) and differentially changed metabolites (FDR < 0.1) that map to the rat-specific metabolic mode. (B) A PCA of the normalized gene counts that map back to the rat-specific heart model demonstrate clear separation, similar to the PCA of all gene counts (Fig 2), confirming that metabolism has a large determinant in separating conditions.
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term side effectsstandard gene enrichmentmetabolomics approaches identifycommonly affected pathwaysmetabolomics data characterizingpresent paired transcriptomicsdiv >< punique metabolic reactionsmetabolomics data integratedpaired datametabolic reactionsmetabolic demandvitro rna synthesisrevealed longphospholipid metabolismp53 pathwayfind evidencecomputational model
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