The methyltransferase inhibitor UNC0638 inhibits SARS-CoV2 proliferation in A549 cells.

A.) IGV plots of SARS-CoV-2 aligned reads from biological replicates of RNA-seq experiments from SARS-CoV-2 infected cells treated with DMSO or UNC0638. B.) Absolute numbers of RNA-seq reads aligned to the SARS-CoV-2 (left panel) or the human genome (right panel). C.) qPCR showing reduction of viral RNA and induction of IFNB1 and IFNL3 (n = 3 for each condition). D.) Gene set enrichment analysis (GSEA) showing that transcripts downregulated by FH-NSP1 transfection are induced upon treatment of SARS-CoV-2 infected A549 cells with UNC0638.