ppat.1009855.g004.tif (340.57 kB)

The majority of SHIV-1157ipd3N4 infected cells are T cells at 96 hours after oral challenge.

figure

posted on 2021-11-18, 18:56 authored by Roslyn A. Taylor, Michael D. McRaven, Ann M. Carias, Meegan R. Anderson, Edgar Matias, Mariluz Araínga, Edward J. Allen, Kenneth A. Rogers, Sandeep Gupta, Viraj Kulkarni, Samir Lakhashe, Ramon Lorenzo-Redondo, Yanique Thomas, Amanda Strickland, Francois J. Villinger, Ruth M. Ruprecht, Thomas J. Hope

Quantification of SHIV-1157ipd3N4 infected cells found in the oral cavity and GI tract of animals examined in Figs 3 and 4. Graphs depict the percentage of infected cell types identified by fluorescent microscopy as parts of a whole. Total cell counts were taken in five 40x panels in every animal. A) Total number of infected cells in all eight neonatal RMs in tongue, tonsil, esophagus, stomach, small intestine, and large intestine. B) Total number of infected cell phenotypes in all eight RMs in the stomach, small intestine, and large intestine. Infected cell types were categorized as five cell types: T cells (CD3+), TH17 T cells (CD3+, CCR6+), CCR6- CD3+ T cells, Immature DCs (CD3-, CCR6+), Other (CD3-, CCR6-).